REV-ERB agonist comes up often in conversation and rarely with the context attached. Here we lay out the basics in order, then work through the practical considerations.
Last reviewed on 2026-01-30. Where a claim depends on a specific study, the study is described rather than over-claimed.
SR9009 is often grouped with compounds studied for circadian and metabolic regulation rather than with classical anabolic steroids. Its interactions with nuclear receptors differ from those of androgen receptor ligands, and its proposed mechanisms involve transcriptional control rather than direct hormone signaling. Some sources classify it as a metabolic modulator because of observed effects on energy utilization. The distinction matters for regulation and for interpreting research results across different compound classes.
SR9009 is a synthetic small molecule developed as a REV-ERB agonist. It binds to REV-ERBα and REV-ERBβ, nuclear receptors that help regulate circadian rhythms and metabolic gene expression. In cell and animal studies, the compound alters lipid and glucose handling and influences skeletal muscle oxidative capacity. Its exact effects in humans remain largely uncharacterized because controlled clinical trials have not been reported. The molecule is frequently described in preclinical literature as a metabolic modulator.
Handling recommendations for SR9009 in a laboratory setting include storing the solid at low temperature, protected from light and moisture. The compound is often dissolved in dimethyl sulfoxide or ethanol for experiments. Solutions should be prepared with appropriate personal protective equipment and disposed of according to local rules. Stability data for long-term storage are limited, so stock solutions are typically kept cold and used within defined periods. Records of preparation date and concentration support reproducibility.
SR9009 is not approved as a medicine by major regulatory agencies. It is commonly sold as a research chemical, a category that may fall outside customary drug approval and quality rules. In sports, the World Anti-Doping Agency lists SR9009 as a prohibited substance. Athletes who use it can face sanctions if it is detected in a sample. Legal status varies by country, and importation may be restricted. Enforcement practices differ across borders.
Detection of SR9009 in biological samples usually employs liquid chromatography coupled with tandem mass spectrometry. This method can identify the parent compound and sometimes metabolites in urine or blood. Because exposure can be low and clearance may be rapid, sample timing and limits of detection matter. Laboratories validate assays for sensitivity and specificity. Results are interpreted alongside chain-of-custody and quality-control records. Urine is the common matrix for anti-doping analysis, while blood may be used in research settings.
| Property | Value | Notes |
|---|---|---|
| Molecular formula | C20H24ClN3O4S | Reported for the free base |
| Molecular weight | 437.9 g/mol | Calculated from the formula |
| Primary target | REV-ERBα and REV-ERBβ | Nuclear receptors involved in circadian regulation |
| Solubility | Soluble in DMSO and ethanol | Poorly soluble in water |
| Typical storage | -20 °C, desiccated | Protect from light and moisture |
SR9009 binds REV-ERB receptors and alters their repressive activity on target genes. This action can change transcription of genes involved in lipid handling, glucose metabolism, and mitochondrial function. In rodent studies, treated animals have shown changes in muscle oxidative capacity and exercise performance, though effects vary by dose, duration, and model. The precise molecular steps connecting receptor binding to whole-body outcomes are still an active area of investigation. Findings in animals do not automatically translate to humans.
Because REV-ERB receptors are core clock components, SR9009 has been examined for effects on daily rhythms as well as metabolism. Research has explored whether the compound can shift or reinforce circadian gene expression in tissues such as liver and muscle. Some studies report improved metabolic markers in obese or diabetic mice, while others show context-dependent responses. Questions remain about which effects are direct, which are secondary to timing, and how they might differ across species.
SR9009 is a synthetic small molecule studied as an agonist of REV-ERB nuclear receptors. REV-ERB alpha and REV-ERB beta help regulate circadian rhythms and metabolic gene expression. In laboratory research, SR9009 has been used to probe how these receptors affect skeletal muscle, liver, and adipose tissue. The compound was identified in academic drug-discovery work and is often described in scientific literature by its chemical name and research code. It is not an approved medicine, and human clinical data remain limited or absent.
All physicians can diagnose mental disorders and prescribe treatments utilizing principles of psychiatry. Psychiatrists are trained physicians who specialize in psychiatry and are certified to treat mental illness. They may treat outpatients, inpatients, or both; they may practice as solo practitioners or as members of groups; they may be self-employed, be members of partnerships, or be employees of governmental, academic, nonprofit, or for-profit entities; employees of hospitals; they may treat military personnel as civilians or as members of the military; and in any of these settings they may function as clinicians, researchers, teachers, or some combination of these. Although psychiatrists may also go through significant training to conduct psychotherapy, psychoanalysis or cognitive behavioral therapy, it is their training as physicians that differentiates them from other mental health professionals.
In 2022, Peña ran successfully to stand as the Colorado Party's presidential candidate; he was widely seen as the candidate most closely aligned to former president Horacio Cartes, while his opponent, Arnoldo Wiens, was aligned with Abdo Benítez. Critics of Peña have said that if elected president, Horacio Cartes would be a grey eminence and that Peña would merely act as a mouthpiece for Cartes, who is sanctioned by the U.S. as "significantly corrupt". Colorado Party politician Blanca Ovelar said Peña would end up acting as a "secretary" to Cartes if he was elected. Cartes and his supporters in Congress had previously attempted to pass a constitutional amendment to allow Cartes to run for re-election, sparking riots in the country. Peña was elected President of Paraguay, after winning 43.9% of the vote in the 2023 general election in April, defeating his closest rival Efraín Alegre by a difference of 15 percentage points. He was congratulated by outgoing president Mario Abdo Benítez, and presidents Luiz Inácio Lula da Silva of Brazil and Alberto Fernández of Argentina. Peña called for unity to address the economic challenges the country is currently facing. Peña was inaugurated on 15 August 2023. At 44 years old, he became Paraguay's youngest president since the restoration of democracy in 1989, surpassing Abdo Benítez, who was 46 when he assumed the role in 2018. On 28 September 2025, protests began in Paraguay against Peña's government.
Consumption in the 20th and 21st centuries has been abundantly pushed by automobile sector growth. The 1985–2003 oil glut even fueled the sales of low fuel economy vehicles in OECD countries. The 2008 economic crisis seems to have had some impact on the sales of such vehicles; still, in 2008 oil consumption showed a small increase. In 2016 Goldman Sachs predicted lower demand for oil due to emerging economies concerns, especially China. The BRICS (Brasil, Russia, India, China, South Africa) countries might also kick in, as China briefly had the largest automobile market in December 2009. In the long term, uncertainties linger; the OPEC believes that the OECD countries will push low consumption policies at some point in the future; when that happens, it will definitely curb oil sales, and both OPEC and the Energy Information Administration kept lowering their 2020 consumption estimates during the past five years. A detailed review of International Energy Agency oil projections have revealed that revisions of world oil production, price and investments have been motivated by a combination of demand and supply factors. All together, non-OPEC conventional projections have been fairly stable the last 15 years, while downward revisions were mainly allocated to OPEC. Upward revisions are primarily a result of US tight oil.
The enzyme is an oxidoreductase that uses molecular oxygen in a multi-step oxidation reaction which specifically converts one terminal methyl group of the steroid to its corresponding bile acid. It requires adrenal ferredoxin to transfer electrons from nicotinamide adenine dinucleotide phosphate to the cytochrome P450 active site. The systematic name of this enzyme class is 5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating). Other names in common use include 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, sterol 27-hydroxylase, sterol 26-hydroxylase, cholesterol 27-hydroxylase, CYP27A, CYP27A1, and cytochrome P450 27A1'.
After dendritic cells have phagocytosed pathogens, they usually migrate to the vast network of lymph vessels and are carried by lymph flow to the draining lymph nodes. Each lymph node is a collection point where APCs can interact with T cells. During the migration, DCs undergo a process of maturation: they lose most of their ability to further engulf pathogens and they mature by changing surface expression of MHC and co-stimulatory molecules, as well as increased production of cytokines. The internalized antigen is digested into smaller peptides containing epitopes, which are then presented to T cells by the MHC. B cells reside in the lymph node. Once their B cell receptor binds to an antigen, they can interact with activated helper T cells, as described above. A dendritic cell that interacts with an already-activated helper T cell can become licensed. This occurs through the interaction of co-stimulatory molecules including B7 and CD40 on the dendritic cell, with CD28 and CD40 ligand on the T cell. Only licensed dendritic cells are able to activate cytotoxic T cells. T cell licensing of dendritic cells is key for activation of cytotoxic T cells for many pathogens, although the extent to which T cell help is needed may vary. In MHC class I and class II molecules, only certain epitopes of an internalized peptide can be presented. These epitopes are termed immunodominant.
Sources: en.wikipedia.org
The xenon pit is a phenomenon of excess neutron absorption through 135Xe buildup in the reactor after a reduction in power or a shutdown and is often managed by letting the 135Xe decay away to a level at which neutron flux can be safely controlled via control rods again. A nuclear reactor will also produce much smaller amounts of 135Cs from the nonradioactive fission product 133Cs by successive neutron capture to 134Cs and then 135Cs. The thermal neutron capture cross section and resonance integral of 135Cs are 8.3 ± 0.3 and 38.1 ± 2.6 barns respectively. Disposal of 135Cs by nuclear transmutation is difficult, because of the low cross section as well as because neutron irradiation of mixed-isotope fission caesium produces more 135Cs from stable 133Cs. In addition, the intense medium-term radioactivity of 137Cs makes handling of nuclear waste difficult.
== History == The US Food and Drug Administration (FDA) approved sotagliflozin based on evidence from two clinical trials of 11,806 total participants with heart failure or with type 2 diabetes, chronic kidney disease, and other cardiovascular risk factors. The trials were conducted at 322 sites in 32 countries (SOLOIST/NCT03521934) and 750 sites in 42 countries (SCORED/NCT03315143) primarily in Europe, South America, and North America. Both trials were used for primary determination of the benefits and side effects of the drug. The benefits and side effects of sotagliflozin were evaluated in the two clinical trials. In both trials, participants were randomly assigned to receive either sotagliflozin or placebo by mouth once a day. Neither the participants nor the healthcare providers knew which treatment was being given until after the trial was completed. The benefit of sotagliflozin was evaluated by measuring the number of predefined events (death from cardiovascular causes, need for hospitalization for heart failure, or urgent medical care visit for heart failure) occurring in the patient population receiving sotagliflozin versus placebo.
His military friend was quoted as saying that their unit was allegedly deployed to South Ossetia for the exercises, but suddenly the war broke out. On 26 August 2008, Drug dlya druga reported that one mother was told by her son on 6 August that his company would be sent to South Ossetia on 9 August. At 3 am on 8 August her son was sent to Tskhinvali, where he was wounded. On 27 August 2008, Vecherny Saransk reported that Yunir Bikkinyaev, contract soldier of 135th Regiment, stopped to answer the phone calls on 7 August and his parents were worried. He later acknowledged he did so not to frighten his family. On 28 August 2008, Gazeta Yuga published a report about Zalim Gegraev, a wounded soldier from 1st company of the peacemaking battalion, who fought in South Ossetia. Gegraev's mother said that her son had told her that he was going to Tskhinvali before the war started. She also said that he had been to South Ossetia previously and when he was there, his phone did not work. Then Zalim spoke to journalist: "We had been there to participate in military exercises for a month in those areas before this. They ended, however we were not withdrawn. Then the order came to move to Tskhinvali. On 8 August we were near the town and waited for further instructions. I didn't even think that I could see such thing..."
Lucilia spp. (green-bottle fly) Cochliomyia spp. (screw-worm fly) Phormia spp. (black-bottle fly) Calliphora spp. (blue-bottle fly) Sarcophaga spp. (flesh fly or sarcophagids) Flesh flies, or sarcophagids, members of the family Sarcophagidae, can cause intestinal myiasis in humans if the females deposit larvae on meat or fruit.
Sources: en.wikipedia.org
Sindone.org – official site of the custodians of the shroud in Turin Professor Creates 3D Image From Shroud The Shroud of Turin Website – Shroud of Turin Education and Research Association, Inc. website Turin Shroud Center of Colorado – research center of John Jackson, a leading member of the STURP team Good Science, Bad Science, and the Shroud of Turin – 2014 NYUAD Chemistry lecture on YouTube Unwrapping the Shroud – 2009 Discovery channel documentary on YouTube Shroud of Turin Evidence – 2008 BBC documentary on YouTube Barrie Schwortz interview – EWTN interview with photographer Barrie Shwortz on YouTube
==== Antarctic plate ==== Marion hotspot (25) 46°54′S 37°36′E, w= 0.5 az= 080° ±12° Crozet hotspot (52) 46°06′S 50°12′E, w= 0.8 az= 109° ±10° rate= 25 ±13 mm/yr Possibly related to the Karoo-Ferrar geologic province (183 Ma) Kerguelen hotspot (20) 49°36′S 69°00′E, w= 0.2 az= 050° ±30° rate= 3 ±1 mm/yr Related to the Kerguelen Plateau (130 Ma) Heard hotspot (53), possibly part of Kerguelen hotspot 53°06′S 73°30′E, w= 0.2 az= 030° ±20° Île Saint-Paul and Île Amsterdam could be part of the Kerguelen hotspot trail (St. Paul is possibly not another hotspot) Balleny hotspot (2) 67°36′S 164°48′E, w= 0.2 az= 325° ±7° Erebus hotspot (54) 77°30′S 167°12′E
==== United nations ==== The UN Commission on Narcotic Drugs added 2C-B to Schedule II of the Convention on Psychotropic Substances in March 2001. 2C-B is a scheduled drug in most jurisdictions. The following is a partial list of territories where the substance has been scheduled.
Sources: en.wikipedia.org
It is a synthetic REV-ERB agonist used mainly in preclinical research. It is not an approved medicine for human use.
It binds to REV-ERBα and REV-ERBβ, nuclear receptors involved in circadian and metabolic gene regulation. This can alter transcription of genes related to lipid and glucose metabolism in experimental models.
No controlled human trials have established that effect. Endurance findings come primarily from rodent studies, and human responses remain unknown.
Its legal status depends on the country and intended use. It is not an approved medicine in major jurisdictions. In sport, it is prohibited by anti-doping rules.